The Host-Pathogen Biology Group

The Host-Pathogen Group is a diverse group of scientists with expertise in microbiology, virology, immunology, and bacterial pathogenesis. Scientists in this group conduct research on host-pathogen interactions with a focus on biothreat viruses and bacteria. Projects include studies of host immune responses during infection using a combination of in vitro and in vivo approaches, vaccine and therapeutic development with an emphasis on broad-spectrum efficacy, viral evolution and cross species transmission, and pathogen characterization and survival in the environment.

Recent Publications

Devault, A.M., McLoughlin, K., Jaing, C., Gardner, S., Porter, T.M., Enk, J.M., Thissen, J., Allen, J., Borucki, M., DeWitte, S.N., Dhody, A.N., Poinar, H.N., 2014. Ancient pathogen DNA in archaeological samples detected with a Microbial Detection Array. Scientific reports 4, 4245.

Feld, G.K., El-Etr, S., Corzett, M.H., Hunter, M.S., Belhocine, K., Monack, D.M., Frank, M., Segelke, B.W., Rasley, A., 2014. Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host-cell invasion. The Journal of biological chemistry.

Fischer, N.O., Blanchette, C., Rasley, A., 2014. Enhancing the efficacy of innate immune agonists: could nanolipoprotein particles hold the key? Nanomedicine 9, 369-372.

Fischer, N.O., Rasley, A., Blanchette, C., 2014. Nanoparticles and antigen delivery: understanding the benefits and drawbacks of different delivery platforms. Nanomedicine 9, 373-376.

Fischer, N.O., Weilhammer, D.R., Dunkle, A., Thomas, C., Hwang, M., Corzett, M., Lychak, C., Mayer, W., Urbin, S., Collette, N., Chiun Chang, J., Loots, G.G., Rasley, A., Blanchette, C.D., 2014. Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform. PloS one 9, e93342.

Gardner, S.N., Jaing, C.J., Elsheikh, M.M., Pena, J., Hysom, D.A., Borucki, M.K., 2014. Multiplex degenerate primer design for targeted whole genome amplification of many viral genomes. Advances in bioinformatics 2014, 101894.

Laurence, T.A., Ly, S., Bourguet, F., Fischer, N.O., Coleman, M.A., 2014. Fluorescence correlation spectroscopy at micromolar concentrations without optical nanoconfinement. The journal of physical chemistry. B 118, 9662-9667.

Ly, S., Bourguet, F., Fischer, N.O., Lau, E.Y., Coleman, M.A., Laurence, T.A., 2014. Quantifying interactions of a membrane protein embedded in a lipid nanodisc using fluorescence correlation spectroscopy. Biophysical journal 106, L05-08.

Westrate, L.M., Drocco, J.A., Martin, K.R., Hlavacek, W.S., MacKeigan, J.P., 2014. Mitochondrial morphological features are associated with fission and fusion events. PloS one 9, e95265.

Borucki, M.K., Allen, J.E., Chen-Harris, H., Zemla, A., Vanier, G., Mabery, S., Torres, C., Hullinger, P., Slezak, T., 2013. The role of viral population diversity in adaptation of bovine coronavirus to new host environments. PloS one 8, e52752.

Borucki, M.K., Chen-Harris, H., Lao, V., Vanier, G., Wadford, D.A., Messenger, S., Allen, J.E., 2013. Ultra-deep sequencing of intra-host rabies virus populations during cross-species transmission. PLoS neglected tropical diseases 7, e2555.

Chen-Harris, H., Borucki, M.K., Torres, C., Slezak, T.R., Allen, J.E., 2013. Ultra-deep mutant spectrum profiling: improving sequencing accuracy using overlapping read pairs. BMC genomics 14, 96.

Drocco, J.A., Olson Reichhardt, C.J., Reichhardt, C., Bishop, A.R., 2013. Static and dynamic phases for magnetic vortex matter with attractive and repulsive interactions. Journal of physics. Condensed matter : an Institute of Physics journal 25, 345703.

Fischer, N.O., Rasley, A., Corzett, M., Hwang, M.H., Hoeprich, P.D., Blanchette, C.D., 2013. Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens. Journal of the American Chemical Society 135, 2044-2047.

Grady, S.L., Purdy, J.G., Rabinowitz, J.D., Shenk, T., 2013. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proceedings of the National Academy of Sciences of the United States of America 110, E5006-5015.

Weilhammer, D.R., Blanchette, C.D., Fischer, N.O., Alam, S., Loots, G.G., Corzett, M., Thomas, C., Lychak, C., Dunkle, A.D., Ruitenberg, J.J., Ghanekar, S.A., Sant, A.J., Rasley, A., 2013. The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge. Biomaterials 34, 10305-10318.